Mixed hyperlipidemia secondary to malnutrition as a cause of non-alcoholic hepatic steatosis
DOI:
https://doi.org/10.70577/asce.v5i2.811Keywords:
hyperlipidemia; desnutrition; steatosis; cirrhosis; lipotoxicityAbstract
The objective of this study was to determine the etiological relationship between mixed hyperlipidemia secondary to malnutrition and the development of nonalcoholic fatty liver disease (NAFLD), elucidating its role in the progression of fibrosis and cirrhosis. Theoretically, the study is based on a "multiple effects" model, where lipotoxicity due to excess cholesterol and triglycerides, added to insulin resistance and dysbiosis of the intestine-liver axis, lead to oxidative stress, mitochondrial dysfunction and hepatocellular infection. Methodologically, a documentary, analytical and descriptive study was carried out through a systematic review based on the PRISMA 2020 guidelines, analyzing 38 scientific articles from international databases published between 2020 and 2025. The results suggest that mixed hyperlipidemia caused by both a diet rich in protein and protein-free nuts is promoted by sugar. Activates fibrogenic pathways, damaging microcirculation.
Furthermore, secondary intestinal dysbiosis and sarcopenia dramatically increase the cirrhotic patient's vulnerability to endotoxins and clinical decompensation.
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