Pre-eclampsia and hypertensive disorders: diagnosis and management

Authors

DOI:

https://doi.org/10.70577/asce.v5i2.785

Keywords:

preeclampsia, hypertensive disorders of pregnancy, diagnosis, clinical management, maternal health

Abstract

This article addresses preeclampsia and hypertensive disorders of pregnancy as a priority maternal and perinatal health problem due to their high clinical burden and their potential to cause serious complications for both mother and fetus. The objective was to analyze recent scientific evidence on the diagnosis and management of these conditions, with an emphasis on current diagnostic criteria, therapeutic strategies, and postpartum follow-up. To this end, a descriptive and analytical literature review was conducted, based on the search, selection, and synthesis of scientific literature published in indexed databases and relevant technical documents. The results showed that the contemporary approach to preeclampsia has moved beyond the diagnostic model limited to proteinuria and adopted a multisystemic perspective based on the identification of maternal organ damage and uteroplacental dysfunction. Furthermore, it was shown that angiogenic biomarkers provided value in risk stratification, that timely antihypertensive treatment and the use of magnesium sulfate remained cornerstones of management, and that determining the timing of delivery continued to be crucial in clinical outcomes. It was concluded that the management of these disorders required a comprehensive, up-to-date, and continuous approach, extending to the postpartum period and the prevention of future cardiovascular risk.

Downloads

Download data is not yet available.

References

Costa, M. L., Cavalli, R. de C., Korkes, H. A., Cunha Filho, E. V. da, & Peraçoli, J. C. (2022). Diagnosis and management of preeclampsia: Suggested guidance on the use of biomarkers. Revista Brasileira de Ginecologia e Obstetrícia, 44(9), 878–883. https://doi.org/10.1055/s-0042-1744286 DOI: https://doi.org/10.1055/s-0042-1744286

Countouris, M. E., & Bello, N. A. (2025). Advances in our understanding of cardiovascular diseases after preeclampsia. Circulation Research, 136(6), 583–593. https://doi.org/10.1161/CIRCRESAHA.124.325581 DOI: https://doi.org/10.1161/CIRCRESAHA.124.325581

Fowosere, V. (2024). Hypertensive disorders in pregnancy: Approach to diagnosis and management in general practice. Australian Journal of General Practice, 53(12 Suppl), S52–S55. https://doi.org/10.31128/AJGP-01-24-7133 DOI: https://doi.org/10.31128/AJGP-01-24-7133

Govindasamy, V., Kamel, M. A., Volucke, G., Javed, A., Palchaudhuri, U., Kazi, S. I., Albanna, A., Akileh, M., Mukherjee, R., Nusrat, R., Qaiser, T., Elzain Hassan, E. I., Azhar, M. M., Hashmi, T. M., Ahmed, M., Hasan, A., & Ahmed, R. (2025). Efficacy and safety of nifedipine compared to intravenous hydralazine for severe hypertensive disorders in pregnancy: A systematic review and meta-analysis of randomised controlled trials. Medical Sciences, 13(3), Article 91. https://doi.org/10.3390/medsci13030091 DOI: https://doi.org/10.3390/medsci13030091

Henry, A., Mangos, G., Roberts, L. M., Brown, M. A., Pettit, F., O’Sullivan, A. J., Crowley, R., Youssef, G., & Davis, G. K. (2024). Preeclampsia-associated cardiovascular risk factors 6 months and 2 years after pregnancy: The P4 study. Hypertension, 81(4), 851–860. https://doi.org/10.1161/HYPERTENSIONAHA.123.21890 DOI: https://doi.org/10.1161/HYPERTENSIONAHA.123.21890

Joanna Briggs Institute. (n.d.). Critical appraisal tools. Retrieved March 31, 2026, from https://jbi.global/critical-appraisal-tools

Lefebvre, C., Glanville, J., Briscoe, S., Featherstone, R., Littlewood, A., Metzendorf, M.-I., Noel-Storr, A., Paynter, R., Rader, T., Thomas, J., & Wieland, L. S. (2025). Chapter 4: Searching for and selecting studies [Last updated March 2025]. In J. P. T. Higgins, J. Thomas, J. Chandler, M. Cumpston, T. Li, M. J. Page, et al. (Eds.), Cochrane Handbook for Systematic Reviews of Interventions (Version 6.5.1). Cochrane. https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04

Magee, L. A., Brown, M. A., Hall, D. R., Gupte, S., Hennessy, A., Karumanchi, S. A., Kenny, L. C., McCarthy, F., Myers, J., Poon, L. C., Rana, S., Saito, S., Staff, A. C., Tsigas, E., & von Dadelszen, P. (2022). The 2021 International Society for the Study of Hypertension in Pregnancy classification, diagnosis & management recommendations for international practice. Pregnancy Hypertension, 27, 148–169. https://doi.org/10.1016/j.preghy.2021.09.008 DOI: https://doi.org/10.1016/j.preghy.2021.09.008

Magee, L. A., Smith, G. N., Bloch, C., Côté, A.-M., Jain, V., Nerenberg, K., von Dadelszen, P., Helewa, M., & Rey, E. (2022). Guideline No. 426: Hypertensive disorders of pregnancy: Diagnosis, prediction, prevention, and management. Journal of Obstetrics and Gynaecology Canada, 44(5), 547–571.e1. https://doi.org/10.1016/j.jogc.2022.03.002 DOI: https://doi.org/10.1016/j.jogc.2022.03.002

Page, M. J., McKenzie, J. E., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow, C. D., Shamseer, L., Tetzlaff, J. M., Akl, E. A., Brennan, S. E., Chou, R., Glanville, J., Grimshaw, J. M., Hróbjartsson, A., Lalu, M. M., Li, T., Loder, E. W., Mayo-Wilson, E., McDonald, S., ... Moher, D. (2021). The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. BMJ, 372, n71. https://doi.org/10.1136/bmj.n71 DOI: https://doi.org/10.1136/bmj.n71

Rajkumar, T., Hennessy, A., & Makris, A. (2025). Remote blood pressure monitoring in pregnancies at risk of developing preeclampsia. Current Hypertension Reports, 27(1), Article 15. https://doi.org/10.1007/s11906-025-01332-9 DOI: https://doi.org/10.1007/s11906-025-01332-9

Tita, A. T., Szychowski, J. M., Boggess, K., Dugoff, L., Sibai, B., Lawrence, K., Hughes, B. L., Bell, J., Aagaard, K., Edwards, R. K., Gibson, K., Haas, D. M., Plante, L., Metz, T., Casey, B., Esplin, S., Longo, S., Hoffman, M., Saade, G. R., ... Andrews, W. W. (2022). Treatment for mild chronic hypertension during pregnancy. New England Journal of Medicine, 386(19), 1781–1792. https://doi.org/10.1056/NEJMoa2201295 DOI: https://doi.org/10.1056/NEJMoa2201295

World Health Organization. (2025, December 10). Pre-eclampsia. https://www.who.int/news-room/fact-sheets/detail/pre-eclampsia

Zhang, L., Feng, Y., Li, W., Sun, Q., Li, Y., Xing, W., & Ding, G. (2025). Predictive performance of sFlt-1, PlGF and the sFlt-1/PlGF ratio for preeclampsia: A systematic review and meta-analysis. Journal of Gynecology Obstetrics and Human Reproduction, 54(4), 102925. https://doi.org/10.1016/j.jogoh.2025.102925 DOI: https://doi.org/10.1016/j.jogoh.2025.102925

Published

2026-04-28

How to Cite

Padilla Yepez, J. M. (2026). Pre-eclampsia and hypertensive disorders: diagnosis and management. ANNALS SCIENTIFIC EVOLUTION, 5(2), 595–610. https://doi.org/10.70577/asce.v5i2.785

Similar Articles

1 2 3 4 5 6 7 8 9 10 > >> 

You may also start an advanced similarity search for this article.