Variability of inflammatory markers in chronic noncommunicable diseases in patients treated in the Internal Medicine Department of SULAB Hospital.
DOI:
https://doi.org/10.70577/asce.v4i4.458Keywords:
Inflammatory biomarkers; Diabetes; Ecuador; Chronic diseases; Hospital epidemiology; Clinical prognosis; Variability.Abstract
Chronic noncommunicable diseases (CNCDs) are associated with low-grade systemic inflammation, and monitoring using biomarkers can provide complementary information to stratify risk and guide clinical decisions. Within this framework, the objective was to evaluate the variability of C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor alpha (TNF-α) and to estimate their diagnostic and prognostic utility in patients with CNN. The study was conducted using an observational and analytical approach, cross-sectional and retrospective, in the Internal Medicine Department of the SULAB Day Hospital from January to December 2024. Secondary sources such as medical records and laboratory logs were used; Data quality criteria were ensured, and statistical analysis was performed using association tests (χ², Cramer's V), establishing significance at p<0.05. Clear and statistically significant differences were found between the biomarkers and the main pathologies evaluated, with IL-6 standing out for its greater discriminatory capacity, while CRP and TNF-α showed associations of intermediate magnitude; the highest values tended to be concentrated in patients with chronic renal failure, compared to other NCDs. Overall, the findings supported that the complementary measurement of IL-6, CRP, and TNF-α improves the detection of systemic inflammation, contributes to longitudinal follow-up, and strengthens the support for decisions that guide personalized care for patients with NCDs, especially in scenarios of clinical heterogeneity where traditional parameters are insufficient to anticipate evolution or therapeutic response.
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